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Journal of Animal Science and Technology
Korean Society of Animal Science and Technology

J Anim Sci Technol

pISSN: 2055-0391, eISSN: 2672-0191

DOI: https://doi.org/10.5187/jast.2022.e114

Article

The roles of growth factors and hormones in the regulation of muscle satellite cells for cultured meat production

Syed Ahmad1,2, Hee Chun1, Khurshid Ahmad1,2, Sibhghatulla Shaikh1,2, Jeong Lim1,2, Shahid Ali1,2, Sung Han2,3, Sun Hur4, Jung Sohn5, Eun Lee1,2, Inho Choi1,2,*
11Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Korea.
22Research Institute of Cell Culture, Yeungnam University, , Gyeongsan 38541 , Korea.
3School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Korea.
4Department of Animal Science and Technology, Chung-Ang University , Anseong 17546, Korea.
55Synthetic Biology and Bioengineering Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
*Corresponding Author: Inho Choi, 1Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Korea, Republic of. 2Research Institute of Cell Culture, Yeungnam University, , Gyeongsan 38541 , Korea, Republic of. E-mail: inhochoi@ynu.ac.kr .

© Copyright 2022 Korean Society of Animal Science and Technology. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Oct 31, 2022; Revised: Nov 25, 2022; Accepted: Nov 27, 2022

Published Online: Dec 20, 2022

Abstract

Cultured meat is a potential sustainable food generated by the <italic>in vitro</italic> myogenesis of muscle satellite (stem) cells (MSCs). The self-renewal and differentiation properties of MSCs are of primary interest for cultured meat production. MSC proliferation and differentiation are influenced by a variety of growth factors such as insulin-like growth factors (IGF-1 and IGF-2), transforming growth factor beta (TGF‐β), fibroblast growth factors (FGF-2 and FGF-21), platelet-derived growth factor (PDGF) and hepatocyte growth factor (HGF) and by hormones like insulin, testosterone, glucocorticoids, and thyroid hormones. In this review, we investigated the roles of MSCs, growth factors, and hormones during cultured meat production because these factors provide signals for MSC growth and structural stability. The role of this article is to provide the important idea about different growth factors such as FGF (enhance the cell proliferation and differentiation), IGF-1 (increase the number of myoblasts), PDGF (myoblast proliferation), TGF-β1 (muscle repair) and hormones such as insulin (cell survival and growth), testosterone (muscle fiber size), dexamethasone (myoblast proliferation and differentiation), and thyroid hormones (amount and diameter of muscle fibers and determine the usual pattern of fiber distributions) as media components during myogenesis for cultured meat production.

Keywords: Muscle satellite cells; Growth factors; Hormones; Myogenesis; Cultured meat