Table 3. Significant (p < 0.05) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enriched for genes within 5-kb flanking region of associated SNP for PRA disease

KEGG Pathway name No. of genes Genes p-value
Cfa04510 Focal adhesion 14 ACTB, DIAPH1, COL6A3, MYLK4, PPP1R12A, ITGA11, RELN, PDGFD, COL5A2, COL11A1, PIK3R1, FN1, AKT2, KDR 2.56E-03
Cfa04360 Axon guidance 10 ABLIM1, DCC, EPHA4, CXCR4, ROBO1, NTN4, SEMA3C, ROBO2, EPHB1, RASA1 4.57E-03
Cfa04022 cGMP-PKG signaling pathway 10 MYLK4, PDE5A, PPP1R12A, ADRA1B, ATP1A4, ATP1A1, PRKCE, AKT2, ITPR2, VDAC1 1.98E-02
Cfa04971 Gastric acid secretion 6 SSTR2, SLC26A7, MYLK4, ATP1A4, ATP1A1, ITPR2 3.76E-02
Cfa04611 Platelet activation 8 ACTB, MYLK4, PPP1R12A, COL5A2, COL11A1, PIK3R1, AKT2, ITPR2 4.53E-02
SNP, single nucleotide polymorphism; PRA, progressive retinal atrophy; cGMP, cyclic guanosine monophosphate; PKG, protein kinase G.