| Serum (ng/dL) | Liver (mg/kg) | Excreta (mg/kg) | |||
|---|---|---|---|---|---|
| 14 d | 35 d | ||||
| Cu source × Concentration | |||||
| INO (ppm) | 16 | 7.6 | 9.5 | 1.77 | 34.20 |
| 40 | 9.8 | 9.9 | 1.78 | 64.50 | |
| 80 | 10.8 | 9.4 | 1.87 | 140.30 | |
| 120 | 9.5 | 10.3 | 2.14 | 162.97 | |
| HME (ppm) | 16 | 12.0 | 12.4 | 1.93 | 26.93 |
| 40 | 11.6 | 12.3 | 2.01 | 52.22 | |
| 80 | 11.5 | 10.4 | 1.84 | 123.57 | |
| 120 | 9.2 | 13.3 | 1.73 | 141.63 | |
| Pooled SEM | 0.50 | 0.42 | 0.04 | 11.46 | |
| Contrast | |||||
| INO vs HME | 0.137 | 0.007 | 0.201 | 0.038 | |
| Effect of INO level | |||||
| Linear | 0.743 | 0.586 | 0.008 | < 0.001 | |
| Quadratic | 0.981 | 0.789 | 0.169 | 0.399 | |
| Effect of HME level | |||||
| Linear | 0.230 | 0.911 | 0.184 | < 0.001 | |
| Quadratic | 0.539 | 0.225 | 0.435 | 0.067 | |