| Acute toxic studies |
| 401 | Acute oral toxicity | Mammalian | 5 males and 5 females | Both | < 24 hours |
| 402 | Acute dermal toxicity: fixed dose procedure | Adult rat or healthy young adult animals | Sequential manner with 2 animals | Female | < 24 hours |
| 403 | Acute inhalation toxicity | Healthy young adult animals | 5 males and 5 females | One or both | 4 - 6 hours |
| 404 | Acute dermal irritation/corrosion | Albino rabbit or healthy young adult rabbits | - | - | 4 hours |
| 405 | Acute eye irritation/corrosion | Albino rabbit or healthy young adult rabbits | - | - | 8 – 24 hours |
| 420 | Acute oral toxicity – fixed dose procedure | Rodent species or healthy young animals | 5 animals | Female | < 24 hours |
| 423 | Acute oral toxicity – acute toxic class method | Rodent species or healthy young animals | 6 animals (3 animals per step) | Female | < 24 hours |
| 425 | Acute oral toxicity: up-and-down procedure | Rodent species or healthy young adult animals | 5 animals | Female | < 24 hours |
| Sub-chronic toxic studies |
| 407 | Repeated dose 28-day oral toxicity study in rodents | Rat or other rodents | 5 females and 5 males | Both | 28 days |
| 408 | Repeated dose 90-day oral toxicity study in rodents | Rat or other rodents | 10 females and 10 males | Both | 90 days |
| 409 | Repeated dose 90-day oral toxicity study in non-rodents | Dogs, pigs, or mini-pigs | 4 females and 4 males | Both | 90 days |
| 410 | Repeated dose dermal toxicity: 21/28-day study | Adult rat, rabbit, or guinea pigs | 5 females and 5 males | Both | 21/28 days |
| 411 | Subchronic dermal toxicity: 90-day study | Adult rat, rabbit, or pigs | 10 females and 10 males | Both | 90 days |
| 413 | Subchronic inhalation toxicity: 90-day study | Healthy young adult rodents | 10 females and 10 males | Both | 90 days |
| Chronic toxic studies |
| 452 | Chronic toxicity studies | Rodents | 20 animals per sex per group | Both | 12 months |