Table 4
Effects of dietary supplementations of 100 ppm of ZnO without (BASAL) or with 120 ppm of apramycin (ANTIBIO), 2,500 ppm of ZnO (HIGH), and 100 ppm of the lipid-encapsulated ZnO (LE) on histological measurements of the intestine in weanling pigs challenged with 5 × 10⁸ cfu of ETEC K88

Item	BASAL	ANTIBIO	HIGH	LE	SEM	P-value
Goblet cell density, cells/mm²
Duodenum
Villus	143^b	145^b	230^a	211^a	13.2	<0.01
Crypt	215^b	221^b	377^a	356^a	24.3	<0.01
Jejunum
Villus	102^d	134^c	164^b	192^a	9.1	<0.01
Crypt	241^c	260^c	305^b	349^a	11.1	<0.01
Ileum
Villus	187	196	192	183	18.7	0.97
Crypt	409	403	439	428	15.0	0.32
Colon
Mucosa	475^b	515^b	624^a	675^a	32.8	<0.01
Mucosal morphology
Duodenum
VH¹, μm	367	386	424	435	19	0.07
CD², μm	254	252	262	256	11	0.93
VH:CD	1.45	1.53	1.62	1.72	0.08	0.10
Jejunum
VH, μm	331	340	305	336	17	0.52
CD, μm	257^a	255^a	200^b	205^b	17	0.04
VH:CD	1.31	1.41	1.52	1.64	0.10	0.12
Ileum
VH, μm	297	300	295	305	9	0.89
CD, μm	250	239	229	224	7	0.06
VH:CD	1.19^a	1.26^a	1.29^ab	1.36^b	0.03	0.02