Table 6. Effect of dietary 3,4,5-trihydroxybenzoic acid and oregano supplementation on blood cytokine concentration of coccidiosis challenged broiler chickens1)
| Period | Dietary treatment2) | SEM | p-value |
| NCNT | CNT | THB | COM 100 | COM 150 | COM 200 |
| 4 dpi |
| IL-1β (ng/mL) | 1.67 | 8.58 | 8.47 | 7.49 | 7.55 | 8.27 | 1.225 | 0.588 |
| IL-10 (ng/mL) | 6.20 | 8.14 | 8.14 | 7.16 | 7.86 | 7.94 | 1.526 | 0.999 |
| IFN-γ (ng/mL) | 2.21 | 4.44 | 4.02 | 3.61 | 3.86 | 3.93 | 0.552 | 0.914 |
| TNF-α (pg/mL) | 13.62 | 22.50 | 20.20 | 18.00 | 18.45 | 18.91 | 2.582 | 0.964 |
| 7 dpi |
| IL-1β (ng/mL) | 6.21 | 11.65 | 9.46 | 10.73 | 9.88 | 10.65 | 1.306 | 0.899 |
| IL-10 (ng/mL) | 16.96 | 16.82 | 19.07 | 15.65 | 18.36 | 18.15 | 2.013 | 0.998 |
| IFN-γ (ng/mL) | 1.96 | 4.42 | 3.82 | 3.76 | 4.21 | 4.44 | 0.599 | 0.867 |
| TNF-α (pg/mL) | 6.48 | 9.70 | 7.63 | 6.54 | 7.07 | 7.38 | 1.014 | 0.959 |
Values are the mean of six replicates per treatment.
NCNT, non-challenged without any dietary treatment; CNT, challenged without any dietary treatment; THB, CNT with 3,4,5-trihydroxybenzoic acid at 0.1 g per kg; COM 100, CNT with combination of THB and oregano extract at 0.1 g per kg; COM 150, CNT with combination of THB and oregano extract at 0.15 g per kg; COM 200, CNT with combination of THB and oregano extract at 0.2 g per kg.
dpi, days post-infection; IL-1β, interleukin-1 beta; IL-10, interleukin-10; IFN-γ, interferon-gamma; TNF-α, tumor necrosis factor-alpha.