Table 4. Pathway analysis of significantly different urine metabolites compared with healthy and subclinical ketosis group

Metabolic pathway	Total Cmpd	Hits1)	p-value	−Log (p-value)	FDR2)	Impact3)
Ubiquinone and other terpenoid-quinone biosynthesis	9	1	4.02 × 10−3	2.40	1.33 × 10−2	0.00
Alanine, aspartate and glutamate metabolism	28	1	4.47 × 10−3	2.35	1.33 × 10−2	0.00
Selenocompound metabolism	20	1	4.47 × 10−3	2.35	1.33 × 10−2	0.00
Aminoacyl-tRNA biosynthesis	48	1	4.47 × 10−3	2.35	1.33 × 10−2	0.00
Valine, leucine and isoleucine degradation	40	1	4.52 × 10−3	2.34	1.33 × 10−2	0.01
Valine, leucine and isoleucine biosynthesis	8	1	4.52 × 10−3	2.34	1.33 × 10−2	0.00
Pentose phosphate pathway	22	2	5.17 × 10−3	2.29	1.33 × 10−2	0.05
Tyrosine metabolism	42	2	7.41 × 10−3	2.13	1.67 × 10−2	0.06
Starch and sucrose metabolism	18	1	1.47 × 10−2	1.83	2.95 × 10−2	0.07
Primary bile acid biosynthesis	46	1	3.33 × 10−2	1.48	6.00 × 10−2	0.02
Tryptophan metabolism	41	1	4.57 × 10−2	1.34	7.48 × 10−2	0.00

The actually matched number from the user uploaded data.
The p-value adjusted using False Discovery Rate.
The pathway impact value calculated from pathway topology analysis.
Total Cmpd, The total number of compounds in the pathway.