Table 8. The results of gene ontology (GO) analysis of differentially expressed genes (Cellular component, Molecular function and Biological process) in the small intestine (ileum) between control and salmonella-infected group

GO ID Description #Genes Enrichment p-value Gene Name
Gene ontology cellular component
 GO:0044421 Extracellular region part 8 6.34 7.60E-06 DCN, PI15, CPXM1, BGN, COL3A1, BPI, DKK2, LRRC17
 GO:0005576 Extracellular region 8 4.86 5.55E-05 DCN, PI15, CPXM1, BGN, COL3A1, BPI, DKK2, LRRC17
 GO:0005615 Extracellular space 6 5.46 3.93E-04 PI15, CPXM1, COL3A1, BPI, DKK2, LRRC17
 GO:0031012 Extracellular matrix 3 13.74 0.001178 DCN, BGN, COL3A1
 GO:0062023 Collagen-containing extracellular matrix 2 18.95 0.004772 DCN, COL3A1
 GO:0038037 G protein-coupled receptor dimeric complex 1 83.36 0.011939 CALCRL
 GO:0097648 G protein-coupled receptor complex 1 69.49 0.014311 CALCRL
 GO:0044420 Extracellular matrix component 1 52.12 0.019039 COL3A1
 GO:0001917 Photoreceptor inner segment 1 46.33 0.021395 ASRGL1
 GO:0005581 Collagen trimer 1 19.85 0.049261 COL3A1
Gene ontology molecular function
 GO:0005201 Extracellular matrix structural constituent 2 68.58 3.54E-04 DCN, COL3A1
 GO:0008238 Exopeptidase activity 2 24.00 0.002947 CPXM1, ASRGL1
 GO:0008528 G protein-coupled peptide receptor activity 2 12.80 0.010075 AGTR1, CALCRL
 GO:0001653 Peptide receptor activity 2 12.63 0.010336 AGTR1, CALCRL
 GO:0030021 Extracellular matrix structural constituent conferring compression resistance 1 96.02 0.010375 DCN
 GO:0004181 Metallocarboxypeptidase activity 1 48.01 0.020653 CPXM1
 GO:0004180 Carboxypeptidase activity 1 34.29 0.028805 CPXM1
 GO:0017046 Peptide hormone binding 1 32.07 0.030833 CALCRL
 GO:0001530 Lipopolysaccharide binding 1 28.24 0.034878 BPI
 GO:0008137 NADH dehydrogenase (ubiquinone) activity 1 28.24 0.034878 ND6
Gene ontology biological process
 GO:0018149 Peptide cross-linking 2 133.64 8.75E-05 BGN, COL3A1
 GO:0060415 Muscle tissue morphogenesis 2 37.42 0.001223 ZFPM2, COL3A1
 GO:0048644 Muscle organ morphogenesis 2 32.26 0.001648 ZFPM2, COL3A1
 GO:0002683 Negative regulation of immune system process 3 10.71 0.002343 COL3A1, BPI, LRRC17
 GO:0007507 Heart development 3 9.48 0.003318 ZFPM2, CALCRL, COL3A1
 GO:0033002 Muscle cell proliferation 2 18.71 0.004849 ZFPM2, CALCRL
 GO:0051241 Negative regulation of multicellular organismal process 4 5.13 0.005729 ZFPM2, COL3A1, BPI, LRRC17
 GO:0048514 Blood vessel morphogenesis 3 7.67 0.006035 ZFPM2, CALCRL, COL3A1
 GO:0001568 Blood vessel development 3 6.85 0.008274 ZFPM2, CALCRL, COL3A1
 GO:0045596 Negative regulation of cell differentiation 3 6.81 0.008386 ZFPM2, COL3A1, LRRC17