Table 3. Gene Ontology and KEGG pathway enrichment analyses of the top 10 differentially expressed miRNAs of Holstein mature milk–derived extracellular vesicles in the comparison between Holstein colostrum– and Holstein mature milk–derived extracellular vesicles

GO ID	GO term	p-value	Pathway ID	Definition	p-value
GO:0030198	Extracellular matrix organization	< 0.001	bta04974	Protein digestion and absorption	< 0.001
GO:0001836	Release of cytochrome c from the mitochondria	0.001	bta04510	Focal adhesion	< 0.001
GO:0097192	Extrinsic apoptotic signaling pathway in the absence of ligand	0.003	bta04151	PI3K-Akt signaling pathway	< 0.001
GO:0071456	Cellular response to hypoxia	0.025	bta04512	ECM–receptor interaction	< 0.001
GO:0051781	Positive regulation of cell division	0.034	bta04926	Relaxin signaling pathway	0.001
GO:0045893	Positive regulation of transcription, DNA-templated	0.035	bta05165	Human papillomavirus infection	0.001
GO:0060070	Canonical Wnt signaling pathway	0.036	bta05222	Small cell lung cancer	0.001
GO:0051897	Positive regulation of protein kinase B signaling	0.037	bta05200	Pathways in cancer	0.005
GO:0010595	Positive regulation of endothelial cell migration	0.043	bta01521	EGFR tyrosine kinase inhibitor resistance	0.009
GO:0008630	Intrinsic apoptotic signaling pathway in response to DNA damage	0.049	bta05205	Proteoglycans in cancer	0.018

Only the top 10 GO terms representing the biological process and KEGG pathway are listed in the table.
KEGG, Kyoto Encyclopedia of Genes and Genomes; PI3K, phosphatidylinositol-3-kinase; ECM, extracellular matrix; EGFR, epidermal growth factor receptor.