Table 4. Gene Ontology and KEGG pathway enrichment analyses of the top 10 differentially expressed miRNAs of Jersey colostrum–derived extracellular vesicles in the comparison between Jersey colostrum– and Jersey mature milk–derived extracellular vesicles

GO ID	GO term	p-value	Pathway ID	Definition	p-value
GO:0008285	Negative regulation of cell proliferation	0.001	bta04150	mTOR signaling pathway	< 0.001
GO:0016310	Phosphorylation	0.002	bta04010	MAPK signaling pathway	0.001
GO:0045669	Positive regulation of osteoblast differentiation	0.006	bta04068	FoxO signaling pathway	0.001
GO:0030178	Negative regulation of the Wnt signaling pathway	0.006	bta05224	Breast cancer	0.003
GO:0001764	Neuronal migration	0.008	bta05202	Transcriptional misregulation in cancer	0.007
GO:0006915	Apoptotic process	0.010	bta05225	Hepatocellular carcinoma	0.008
GO:0001935	Endothelial cell proliferation	0.012	bta05210	Colorectal cancer	0.010
GO:0051726	Regulation of cell cycle	0.017	bta05223	Nonsmall cell lung cancer	0.014
GO:0030154	Cell differentiation	0.018	bta05200	Pathways in cancer	0.022
GO:0035556	Intracellular signal transduction	0.023	bta04950	Maturity onset diabetes of the young	0.033

Only the top 10 GO terms representing the biological process and KEGG pathway are listed in the table.
KEGG, Kyoto Encyclopedia of Genes and Genomes; mTOR, mammalian target of rapamycin; MAPK, mitogen-activated protein kinase; FoxO, forkhead box O.