Table 5. Gene Ontology and KEGG pathway enrichment analyses of the top 10 differentially expressed miRNAs of Jersey mature milk–derived extracellular vesicles in the comparison between Jersey colostrum– and Jersey mature milk–derived extracellular vesicles

GO ID	GO term	p-value	Pathway ID	Definition	p-value
GO:0034599	Cellular response to oxidative stress	< 0.001	bta04010	MAPK signaling pathway	0.001
GO:0043162	Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	0.002	bta05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	0.002
GO:0071333	Cellular response to glucose stimulus	0.002	bta04360	Axon guidance	0.003
GO:0010458	Exit from mitosis	0.002	bta04912	GnRH signaling pathway	0.006
GO:0010508	Positive regulation of autophagy	0.003	bta04218	Cellular senescence	0.009
GO:0071805	Potassium ion transmembrane transport	0.004	bta04921	Oxytocin signaling pathway	0.017
GO:0010737	Protein kinase A signaling	0.005	bta04068	FoxO signaling pathway	0.017
GO:0009408	Response to heat	0.011	bta04720	Long-term potentiation	0.017
GO:0010766	Negative regulation of sodium ion transport	0.011	bta04550	Signaling pathways regulating pluripotency of stem cells	0.028
GO:0030036	Actin cytoskeleton organization	0.017	bta05216	Thyroid cancer	0.031

Only the top 10 GO terms representing the biological process and KEGG pathway are listed in the table.
KEGG, Kyoto Encyclopedia of Genes and Genomes; MAPK, mitogen-activated protein kinase; PD-L1, programmed death ligand 1; PD-1, programmed cell death protein 1; GnRH, gonadotropin-releasing hormone; FoxO, forkhead box O.