Table 8. Gene Ontology and KEGG pathway enrichment analyses of the top 7 miRNAs of Holstein colostrum–derived extracellular vesicles

GO ID	GO term	p-value	Pathway ID	Definition	p-value
GO:0001764	Neuronal migration	< 0.001	bta05200	Pathways in cancer	< 0.001
GO:0006468	Protein phosphorylation	< 0.001	bta04068	FoxO signaling pathway	< 0.001
GO:0010718	Positive regulation of epithelial to mesenchymal transition	0.002	bta04350	TGF-beta signaling pathway	< 0.001
GO:0015031	Protein transport	0.002	bta05224	Breast cancer	< 0.001
GO:0043491	Protein kinase B signaling	0.003	bta04010	MAPK signaling pathway	0.001
GO:0008285	Negative regulation of cell proliferation	0.004	bta05210	Colorectal cancer	0.001
GO:0030177	Positive regulation of the Wnt signaling pathway	0.009	bta05225	Hepatocellular carcinoma	0.004
GO:0043065	Positive regulation of apoptotic process	0.014	bta05226	Gastric cancer	0.007
GO:0035556	Intracellular signal transduction	0.017	bta04510	Focal adhesion	0.012
GO:0098609	Cell–cell adhesion	0.037	bta04014	Ras signaling pathway	0.014

Only the top 10 GO terms representing the biological process and KEGG pathway are listed in the table.
KEGG, Kyoto Encyclopedia of Genes and Genomes; FoxO, forkhead box O; TGF, transforming growth factor; MAPK, mitogen-activated protein kinase.