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["Additional file 4 Molecular functions  of candidate genes under selection based on gene ontology(GO) analysis"]
["Term","ID","Genes","Count","%","P-Value"]
["protein kinase activity","GO:0004672","Wif1,xrcc6bp1,ADCK1,CAMK2D,Cdkl3,ERN1,mak,Map2k5,MAP3K1,MAP3K14,PIK3C3,PRKCI,RNASEL,BRAF,VRK1,",15,0.9,{"v":0.00084,"d":"8.40E-04"}]
["protein serine/threonine kinase activity","GO:0004674","xrcc6bp1,ADCK1,CAMK2D,Cdkl3,ERN1,mak,Map2k5,MAP3K1,MAP3K14,PRKCI,BRAF,VRK1",12,0.7,{"v":0.0014,"d":"1.40E-03"}]
["adenyl nucleotide binding","GO:0030554","ATP2A3,STEAP3,ADCK1,ACOXL,CAMK2D,chd7,Cdkl3,DGKB,ERN1,Galk2,KIF6,mak,MAGI3,Map2k5,MAP3K1,MAP3K14,MYO1B,PI4KB,PIK3C3,PRKCI,RNASEL,LOC392335, LOC441420, MYO5B,UBE2W,BRAF,VRK1",25,1.5,{"v":0.0047,"d":"4.70E-03"}]
["purine nucleoside binding","GO:0001883","ATP2A3,STEAP3,ADCK1,ACOXL,CAMK2D,chd7,Cdkl3,DGKB,ERN1,Galk2,KIF6,mak,MAGI3,Map2k5,MAP3K1,MAP3K14,MYO1B,PI4KB,PIK3C3,PRKCI,RNASEL,LOC392335, LOC441420, MYO5B,UBE2W,BRAF,VRK1",25,1.5,{"v":0.0057,"d":"5.70E-03"}]
["nucleoside binding","GO:0001883","ATP2A3,STEAP3,ADCK1,ACOXL,CAMK2D,chd7,Cdkl3,DGKB,ERN1,Galk2,KIF6,mak,MAGI3,Map2k5,MAP3K1,MAP3K14,MYO1B,PI4KB,PIK3C3,PRKCI,RNASEL,LOC392335, LOC441420, MYO5B,UBE2W,BRAF,VRK1",25,1.5,{"v":0.0062,"d":"6.20E-03"}]
["ATP binding","GO:0005524","ATP2A3,ADCK1,CAMK2D,chd7,Cdkl3,DGKB,ERN1,Galk2,KIF6,mak,MAGI3,Map2k5,MAP3K1,MAP3K14,MYO1B,PI4KB,PIK3C3,PRKCI,RNASEL,LOC392335, LOC441420, MYO5B,UBE2W,BRAF,VRK1,",23,1.4,{"v":0.0088,"d":"8.80E-03"}]
["adenyl ribonucleotide binding","GO:0032559","ATP2A3,ADCK1,CAMK2D,chd7,Cdkl3,DGKB,ERN1,Galk2,KIF6,mak,MAGI3,Map2k5,MAP3K1,MAP3K14,MYO1B,PI4KB,PIK3C3,PRKCI,RNASEL,LOC392335, LOC441420, MYO5B,UBE2W,BRAF,VRK1",23,1.4,{"v":0.01,"d":"1.00E-02"}]
["MAP kinase kinase kinase activity","GO:0004709","MAP3K1,MAP3K14,BRAF",3,0.2,{"v":0.012,"d":"1.20E-02"}]
["purine nucleotide binding"," GO:0017076","ATP2A3,STEAP3,ADCK1,ACOXL,CAMK2D,chd7,Cdkl3,dock9,DGKB,DNM1L,ERN1,Galk2,KIF6,mak,MAGI3,Map2k5,MAP3K1,MAP3K14,MYO1B,PI4KB,PIK3C3,PRKCI,RNASEL,LOC392335, LOC441420, MYO5B,UBE2W,BRAF,VRK1",27,1.6,{"v":0.014,"d":"1.40E-02"}]
["structural constituent of cytoskeleton","GO:0005200","BICD1,Ctnna2,TLN1,TUBGCP4",4,0.2,{"v":0.027,"d":"2.70E-02"}]
["ribonucleotide binding","GO:0032553","ATP2A3,ADCK1,CAMK2D,chd7,Cdkl3,dock9,DGKB,DNM1L,ERN1,Galk2,KIF6,mak,MAGI3,Map2k5,MAP3K1,MAP3K14,MYO1B,PI4KB,PIK3C3,PRKCI,RNASEL,LOC392335, LOC441420, MYO5B,UBE2W,BRAF,VRK1,",25,1.5,{"v":0.028,"d":"2.80E-02"}]
["purine ribonucleotide binding","GO:0032555","ATP2A3,ADCK1,CAMK2D,chd7,Cdkl3,dock9,DGKB,DNM1L,ERN1,Galk2,KIF6,mak,MAGI3,Map2k5,MAP3K1,MAP3K14,MYO1B,PI4KB,PIK3C3,PRKCI,RNASEL,LOC392335, LOC441420, MYO5B,UBE2W,BRAF,VRK1",25,1.5,{"v":0.028,"d":"2.80E-02"}]
["channel activity","GO:0015267","Ano6,CACNA2D3,CACNB2,Clic5,GABRB2,PANX1,KCNU1,Kcnd3,Trpc4",9,0.5,{"v":0.029,"d":"2.90E-02"}]
["passive transmembrane transporter activity","GO:0022803","Ano6,CACNA2D3,CACNB2,Clic5,GABRB2,PANX1,KCNU1,Kcnd3,Trpc4",9,0.5,{"v":0.029,"d":"2.90E-02"}]
["ion binding","GO:0043167","ATP2A3,BRF2,Fgd2,fancl,FRAS1,Gli3,park2,STEAP3,xrcc6bp1,agl,Ano6,Cdh12,CACNA2D3,CACNB2,CA3,Clic5,CLYBL,DLK1,DGKB,ERN1,EHMT2,GABRB2,INPP1,L3mbtl2,msrb3,Map2k5,MAP3K1,NR2F2,pitpnm2,PIK3C3,KCNU1,Kcnd3,PRKCI,PCDH17,RNASEL,RNF180,SLIT3,SLC10A2, SLC23A2,TSHZ2,Thbs1,Trpc4,BRAF,ZBTB10,Zmym4,Zmynd8",48,2.9,{"v":0.033,"d":"3.30E-02"}]
["mitogen-activated protein kinase kinase binding","GO:0031434","MAP3K1,BRAF",2,0.1,{"v":0.043,"d":"4.30E-02"}]
["nucleotide binding","GO:0000166","ATP2A3,ADCK1,ACOXL,CAMK2D,chd7,Cdkl3,Dach1,dock9,DGKB,DNM1L,ERN1,Galk2,KIF6,mak,MAGI3,Map2k5,MAP3K1,MAP3K14,",28,1.7,{"v":0.05,"d":"5.00E-02"}]
["alkali metal ion binding","GO:0031420","INPP1,KCNU1,Kcnd3,SLC10A2,SLC12A1,SLC23A2,MYO1B,PI4KB,PIK3C3,PRKCI,RNASEL,LOC392335, LOC441420, MYO5B,UBE2W,BRAF,VRK1,",6,0.4,{"v":0.05,"d":"5.00E-02"}]
["ion channel activity","GO:0005216","Ano6,CACNA2D3,CACNB2,Clic5,GABRB2,KCNU1,Kcnd3,Trpc4,",8,0.5,{"v":0.053,"d":"5.30E-02"}]
["gated channel activity","GO:0022836","CACNA2D3,CACNB2,Clic5,GABRB2,KCNU1,Kcnd3,Trpc4,",7,0.4,{"v":0.055,"d":"5.50E-02"}]
["calcium ion binding","GO:0005509","ATP2A3,FRAS1,Ano6,Cdh12,CACNA2D3,CACNB2,DLK1,DGKB,Fbn2,pitpnm2,PCDH17,SLIT3,Thbs1,Trpc4,",14,0.8,{"v":0.059,"d":"5.90E-02"}]
["cation binding","GO:0043169","ATP2A3,BRF2,Fgd2,fancl,FRAS1,Gli3,park2,STEAP3,xrcc6bp1,agl,Ano6,Cdh12,CACNA2D3,CACNB2,CA3,CLYBL,DLK1,DGKB,ERN1,EHMT2,Fbn2,INPP1,L3mbtl2,msrb3,Map2k5,MAP3K1,NR2F2,pitpnm2,PIK3C3,KCNU1,Kcnd3,PRKCI,PCDH17,RNASEL,RNF180,SLIT3,SLC10A2,SLC12A1,SLC23A2,TSHZ2,Thbs1,Trpc4,BRAF,ZBTB10,Zmym4,Zmynd8",46,2.7,{"v":0.06,"d":"6.00E-02"}]
["substrate specific channel activity","GO:0022838","Ano6,CACNA2D3,CACNB2,Clic5,GABRB2,KCNU1,Kcnd3,Trpc4,",8,0.5,{"v":0.061,"d":"6.10E-02"}]
["metal ion binding","GO:0046872","ATP2A3,BRF2,Fgd2,fancl,FRAS1,Gli3,park2,STEAP3,xrcc6bp1,Ano6,Cdh12,CACNA2D3,CACNB2,CA3,CLYBL,DLK1,DGKB,ERN1,EHMT2,Fbn2,INPP1,L3mbtl2,msrb3,Map2k5,MAP3K1,NR2F2,pitpnm2,PIK3C3,KCNU1,Kcnd3,PRKCI,PCDH17,RNASEL,RNF180,",45,2.7,{"v":0.076,"d":"7.60E-02"}]
["glucosidase activity","GO:0015926","agl,GANC,SLIT3,SLC10A2,SLC12A1,SLC23A2,TSHZ2,Thbs1,Trpc4,BRAF,ZBTB10,Zmym4,Zmynd8",2,0.1,{"v":0.084,"d":"8.40E-02"}]
["voltage-gated ion channel activity","GO:0005244","CACNA2D3,CACNB2,Clic5,KCNU1,Kcnd3",5,0.3,{"v":0.093,"d":"9.30E-02"}]
["voltage-gated channel activity","GO:0022832","CACNA2D3,CACNB2,Clic5,KCNU1,Kcnd3",5,0.3,{"v":0.093,"d":"9.30E-02"}]