Comparative analysis of dietary exosome-derived microRNAs from human, bovine and caprine colostrum and mature milk

Bohyun Yun1, Younghoon Kim2, Dong-Jun Park3, Sangnam Oh1,*
Author Information & Copyright
1Department of Functional Food and Biotechnology, Jeonju University, Jeonju 55069, Korea.
2Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Science, Seoul National University, Seoul 08826, Korea.
3Korea Food Research Institute, Wanju 55365, Korea.
*Corresponding Author: Sangnam Oh, Department of Functional Food and Biotechnology, Jeonju University, Jeonju 55069, Korea, Republic of. E-mail:

© Copyright 2021 Korean Society of Animal Science and Technology. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Jan 18, 2021; Revised: Jan 21, 2021; Accepted: Jan 25, 2021

Published Online: Feb 05, 2021


Mammalian milk including microRNAs (miRNAs) as a novel class of noncoding RNAs, that can be transferred to infants and it plays on a critical role in biological functions such as immune regulation and development. However, the origin and functional importance of milk-derived miRNAs are still undetermined. This study applied RNA sequencing to explore the featured profiles of miRNA expression in colostrum and mature milk-originated exosomes from human, bovine, and caprine milk. These dietary exosome-derived miRNAs are highly conserved in human, bovine and caprine milk. Interestingly, abundant miRNAs expressed in human milk are similarly conserved across species. In addition, we confirmed that immune-related miRNAs (miR-30a-5p, miR-22-3p, and miR-26a) are commonly observed in the colostrum and mature milk of cows and caprines as well as humans. Our results provide new insights and resources for investigating the functionality of immune-associated miRNAs and evaluating physiological and biological condition in human, bovine and caprine milk as biomarkers.

Keywords: Colostrum; mature milk; dietary exosome; microRNA; mammals

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